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KMID : 0616120190500020118
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Korean Journal of Pharmacognosy
2019 Volume.50 No. 2 p.118 ~ p.123
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Neuroprotective Effect of Taraxacum platycarpum Extract Against Glutamate-induced Oxidative Stress in HT22 Cells
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Lee Hyun-Woo
Ma Choong-Je
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Abstract
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Glutamate acts as an important neurotransmitter in brain. However, high concentration of glutamate showed an excitatory neurotoxicity and resulted to neuronal cell death. Neuronal cell death is known for one of the reason of Alzheimer’s disease, a neurodegenerative disease. We tried to find neuroprotective medicinal plants by neuroprotection activity against glutamate injured HT22 cells as a model system. In the course of bioscreening of various medicinal plants, Taraxacum platycarpum extract showed significant neuroprotective activity. We tried to elucidate mechanisms of neuroprotective activity. T. platycarpum extract reduced ROS and intracellular Ca2+ concentration increased by glutamate induced neurotoxicity. In addition, mitochondrial membrane potential was restored to the control level. Also, glutathione level, glutathione reductase and glutathione peroxidase activity were increased by T. platycarpum extract treatment. These data suggested that T. platycarpum showed neuroprotective activity via antioxidative activity.
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KEYWORD
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Taraxacum platycarpum, Alzheimer’s disease, ROS, Neuroprotection, Antioxidant
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